User Testing of a Car Accessories E-shop

Import 22/07/2015Cieľom tejto bakalárskej práce je zistiť, ako užívatelia skutočne používajú stránky internetového obchodu s autodoplnkami. V teoretickej časti je pozornosť práce zameraná na východiská obchodovania na internete. Na to nadväzuje praktická časť, ktorá sa zaoberá užívateľským testovaním a následnou analýzou daného internetového obchodu. V závere na základe tejto analýzy boli navrhnuté doporučenia na zlepšenie.The purpose of this bachelor thesis is to observe the behavior of people shopping on online stores which are selling accessories for cars. The theoretical part aims on trading solutions over the internet. The practical part deals with user testing and a subsequent analysis of a particular online store. In conclusion, the bachelor's thesis gives suggestions to improvements based on this analysis.116 - Katedra marketingu a obchoduvýborn

Problematika tzv. dvoukolejnosti systému památkové péče v ČR

This Master’s Thesis considers the theme of the twin track approach in cultural heritage management system in Czech Republic in comparison with system implemented in Slovak Republic in year 2002 where was heritage institute transformed to office. The aim of thesis is to analyze both of cultural heritage management systems and recommend solution based on evaluated outcomes which could improve culture heritage management system in Czech Republic.Diplomová práce se věnuje problematice dvoukolejnosti v systéme památkové péče České republiky, který srovnává se systémem implementovaným po roku 2002 na Slovensku, kde byl Památkový ústav transformován na úřad. Cílem práce je analyzovat oba systémy památkové péče a na základe výsledků jich hodnocení nabídnout řešení, kterými by bylo možné systém památkové péče v České republice zlepšit.Diplomová práca sa venuje problematike dvojkoľajnosti v systéme pamiatkovej starostlivosti Českej republiky, ktorý zrovnáva zo systémom implementovaným po roku 2002 na Slovensku, kde bol Pamiatkový ústavu transformovaný na úrad. Cieľom práce je analyzovať oba systémy pamiatkovej starostlivosti a na základe výsledkov ich hodnotenia ponúknuť riešenia, ktorými by bolo možné systém pamiatkovej starostlivosti v Českej republike zlepšiť

The Benefit of Telemonitoring in the Prevention of Septic Shock in a Patient with Aggressive Non-Hodgkin’s Lymphoma

Telemonitoring is a great tool for vital signs monitoring in patients at high risk of severe life-threatening infections, such as haemato-oncological patients. As it can detect early symptoms of an infection, it allows early reaction and, therefore, can help prevent the progression of the infection into severe sepsis. We present a case report of a 69-year-old patient with aggressive non-Hodgkin lymphoma undergoing intensive immunochemotherapy. The treatment was complicated by two episodes of Gram-negative bacterial (G−) infection. During the first episode, the patient was admitted to the hospital only after developing septic shock with multiorgan dysfunction syndrome, which required vasopressor support and multiple broad-spectrum antibiotics and other antimicrobial therapy. Following this episode, the patient was enrolled in our telemonitoring project focusing on early detection of infections in high-risk haemato-oncological patients. The patient later developed another infection with G− bacteremia; however, thanks to the telemonitoring, he was admitted to the hospital within a few hours after developing (and detecting) fever. The therapy was initiated immediately, and the infection was successfully managed with first-choice antibiotics without any further complications. This case illustrates the importance of early detection of infection in high-risk patients, as well as the benefits of telemonitoring. Moreover, avoidance of septic shock and the consequent need for intensive care can significantly reduce healthcare costs

Promising Immunotherapeutic Modalities for B-Cell Lymphoproliferative Disorders

Over the last few years, treatment principles have been changed towards more targeted therapy for many B-cell lymphoma subtypes and in chronic lymphocytic leukemia (CLL). Immunotherapeutic modalities, namely monoclonal antibodies (mAbs), bispecific antibodies (bsAbs), antibody-drug conjugates (ADCs), and chimeric antigen receptor T (CAR-T) cell therapy, commonly use B-cell-associated antigens (CD19, CD20, CD22, and CD79b) as one of their targets. T-cell engagers (TCEs), a subclass of bsAbs, work on a similar mechanism as CAR-T cell therapy without the need of previous T-cell manipulation. Currently, several anti-CD20xCD3 TCEs have demonstrated promising efficacy across different lymphoma subtypes with slightly better outcomes in the indolent subset. Anti-CD19xCD3 TCEs are being developed as well but only blinatumomab has been evaluated in clinical trials yet. The results are not so impressive as those with anti-CD19 CAR-T cell therapy. Antibody-drug conjugates targeting different B-cell antigens (CD30, CD79b, CD19) seem to be effective in combination with mAbs, standard chemoimmunotherapy, or immune checkpoint inhibitors. Further investigation will show whether immunotherapy alone or in combinatory regimens has potential to replace chemotherapeutic agents from the first line treatment